Ye Rong-wei, Liu Ying-hui, Ma Rui, Ren Ai-guo, Liu Jian-meng
Institute of Reproductive and Child Health, Peking University, Beijing 100191, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Sep;30(9):891-4.
To examine the relationship between pregnancy-induced hypertension (PIH) and risks of perinatal mortality.
A population-based, retrospective cohort study was conducted based on 134 858 women registered in a perinatal health care surveillance system and delivered singleton births between 1995 to 2000 in Zhejiang province, China. Multivariate logistic regression models were employed to estimate the relative risk (OR) and 95%CI.
The perinatal mortality rate (95%CI) was 7.6 per thousand (7.1 - 8.1) in normotensive women and 9.2 per thousand (7.7 - 10.8) in PIH women. The cesarean delivery rate was 45.7% in normotensive women and 55.7% in groups with PIH. When compared with the normotensive women, the unadjusted OR (95%CI) for perinatal mortality was 1.21(1.01 - 1.46) in groups with PIH; 0.97 (0.77 - 1.22) in groups with mild PIH, 1.73 (1.26 - 2.37) in groups with moderate PIH, and 2.01 (1.18 - 3.43) in groups with severe PIH; 0.99 (0.77 - 1.26) in groups with PIH developed before delivery, 1.39 (1.05 - 1.84) in groups with PIH developed in second trimester, and 2.69 (1.54 - 4.69) in groups with PIH developed in third trimester. After controlling for maternal age, occupation, educational attainment, parity, times of prenatal visit, infant's sex, pregnancy complications and cesarean delivery, the OR (95%CI) for perinatal mortality was 1.09 (0.90 - 1.31) in women with PIH when compared with the normotensive groups. The adjusted OR for perinatal mortality was 0.81 (0.64 - 1.02) in groups with mild PIH, 1.94 (1.41 - 2.67) in groups with moderate PIH, and 3.32 (1.92 - 5.75) in groups with severe PIH; 0.82 (0.63 - 1.05) in groups with PIH developed before delivery, 1.51 (1.14 - 2.00) in groups with PIH in second trimester, and 2.67 (1.52 - 4.70) in groups with PIH in third trimester.
Moderate and severe PIH early developed during pregnancy could increase the risk of perinatal mortality, while cesarean delivery could decrease the risks in women with PIH.
探讨妊娠高血压综合征（PIH）与围产期死亡率风险之间的关系。
基于中国浙江省围产期保健监测系统中登记的134858名妇女开展一项基于人群的回顾性队列研究，这些妇女在1995年至2000年间分娩单胎。采用多因素logistic回归模型估计相对风险（OR）和95%可信区间。
血压正常妇女的围产期死亡率（95%CI）为千分之7.6（7.1 - 8.1），PIH妇女为千分之9.2（7.7 - 10.8）。血压正常妇女的剖宫产率为45.7%，PIH组为55.7%。与血压正常妇女相比，PIH组围产期死亡率的未调整OR（95%CI）为1.21（1.01 - 1.46）；轻度PIH组为0.97（0.77 - 1.22），中度PIH组为1.73（1.26 - 2.37），重度PIH组为2.01（1.18 - 3.43）；分娩前发生PIH组为0.99（0.7
