Xiao Wen-kai, Ye Ping, Liu De-jun, Wu Hong-mei, Luo Lei-ming
Second Department of Cardiology, Southern Building Clinic Division, PLA General Hospital, Beijing 100853, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Oct;30(10):1055-9.
The augmentation index (AI) derived from central arteries is generally defined as an index of augmentation of central blood pressure in systole derived from the return of pressure waves reflected from the periphery and is an index of arterial stiffness. There is controversy with respect to how to affect AI.
In a cross-sectional study of 4985 subjects (2417 men and 2568 women) aged 18 - 96 years (50.94 +/- 14.73 years, mean +/- SD), AI was measured in the left radial artery using tonometry Colin HEM-9000AI.
Among the subjects, 39.4% were diagnosed as hypertensive, 11.2% as diabetes mellitus, and 48.7% as hyperlipidemia. Stepwise regression analysis revealed that age, diastolic blood pressure, smoking, heart rate, height, waist circumference and fasting blood glucose were independent determinants of radial AI in women;while in men, it was also determined by total cholesterol. Radial AI was significantly higher in women than in men [(83.18 +/- 12.36)% vs. (71.93 +/- 15.22)%, P < 0.01].
Our findings indicate that AI is determined by arterial stiffness, distance to the reflection point and reflection coefficient. It is necessary to take into account these confounding factors when assessing AI is used as an index for atherosclerosis.
源自中心动脉的增强指数（AI）通常被定义为由于外周反射的压力波折返而导致的收缩期中心血压增强指数，是动脉僵硬度的指标。关于如何影响AI存在争议。
在一项对4985名年龄在18 - 96岁（平均50.94±14.73岁，均值±标准差）的受试者（2417名男性和2568名女性）的横断面研究中，使用科林HEM - 9000AI眼压计在左桡动脉测量AI。
在这些受试者中，39.4%被诊断为高血压，11.2%为糖尿病，48.7%为高脂血症。逐步回归分析显示，年龄、舒张压、吸烟、心率、身高、腰围和空腹血糖是女性桡动脉AI的独立决定因素；而在男性中，还由总胆固醇决定。女性的桡动脉AI显著高于男性[（83.18±12.36）%对（71.93±15.22）%，P < 0.01]。
我们的研究结果表明，AI由动脉僵硬度、到反射点的距离和反射系数决定。在将AI用作动脉粥样硬化指标进行评估时，有必要考虑这些混杂因素。
