Université d'Orléans and Centre National de la Recherche Scientifique, Molecular Immunology and Embryology (IEM), Orléans, France.
Cytokine. 2010 May;50(2):220-7. doi: 10.1016/j.cyto.2010.02.003. Epub 2010 Mar 2.
A proinflammatory role of T helper (Th)17 cells, producing IL-22 and IL-17A, has been favored although there is evidence for negative immune regulation by IL-17A. Here we show that IL-22 was produced during an allergic response in lungs of mice, immunized and challenged with ovalbumin (OVA), and that IL-22 neutralization further augmented the eosinophil recruitment to the lung. In a second allergy model, transfer of OVA-pulsed dendritic cells (DC) into naive mice conveyed eosinophil recruitment in response to subsequent inhaled OVA challenge, while DC preincubation with recombinant IL-22 abolished this response. Similarly, DC preincubation with IL-17A abolished DC-driven eosinophil recruitment, showing that both Th17 cytokines IL-22 and IL-17A mediate negative regulation of allergy by acting on DCs. Therefore, IL-22 inhibits DC functions and attenuates an allergic response.
Th17 细胞产生白细胞介素-22（IL-22）和白细胞介素-17A（IL-17A），发挥促炎作用，尽管有证据表明 IL-17A 具有负性免疫调节作用。在这里，我们发现卵清蛋白（OVA）免疫和激发的小鼠肺部在过敏反应过程中产生了 IL-22，并且 IL-22 中和进一步增强了嗜酸性粒细胞向肺部的募集。在第二个过敏模型中，将 OVA 脉冲树突状细胞（DC）转移到幼稚小鼠中，导致随后吸入 OVA 激发时嗜酸性粒细胞募集，而用重组 IL-22 预处理 DC 则消除了这种反应。同样，用 IL-17A 预处理 DC 消除了 DC 驱动的嗜酸性粒细胞募集，表明 Th17 细胞因子 IL-22 和 IL-17A 通过作用于 DC 来介导过敏的负性调节。因此，IL-22 抑制 DC 功能并减弱过敏反应。
