Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA.
Environ Health Perspect. 2010 Mar;118(3):318-23. doi: 10.1289/ehp.0901332.
Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects.
We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters.
We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression.
TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), 5% to 1%) decline in free thyroxine and a 17% (95% CI, 432%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 219%) increase in prolactin and a 19% (95% CI, 30% to 5%) decrease in sperm concentration.
OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.
有机磷 (OP) 化合物，如三（1,3-二氯-2-丙基）磷酸酯 (TDCPP) 和磷酸三苯酯 (TPP)，通常作为添加剂阻燃剂和增塑剂广泛用于各种材料中。尽管普遍认为人类会接触到 OP 阻燃剂，但关于其潜在健康影响的人类和动物数据却很少。
我们探讨了房屋灰尘中 TDCPP 和 TPP 浓度与激素水平和精液质量参数之间的关系。
我们分析了美国一家不孕诊所招募的 50 名男性的房屋灰尘中的 TDCPP 和 TPP。使用未经调整和多变量线性回归评估它们与生殖和甲状腺激素水平以及精液质量参数之间的关系。
TDCPP 和 TPP 的检出率分别为 96%和 98%，浓度差异很大，最高可达 1.8 毫克/克。在调整了年龄和体重指数的模型中，TDCPP 的四分位距 (IQR) 增加与游离甲状腺素下降 3%（95%置信区间[CI]，5%至 1%）和催乳素增加 17%（95% CI，432%）相关。TDCPP 与游离雄激素指数之间存在提示性的负相关关系，但在调整后的模型中这种关系变得不那么明显。在调整后的模型中，IQR 增加 TPP 与催乳素增加 10%（95% CI，219%）和精子浓度下降 19%（95% CI，30%至 5%）相关。
OP 阻燃剂可能与男性激素水平改变和精液质量下降有关。需要更多关于人类接触 OP 阻燃剂的来源和水平以及相关健康结果的研究。
