Department of Neurology, Hahnemann University Hospital.
Epileptic Disord. 2010 Mar;12(1):59-64. doi: 10.1684/epd.2010.0296. Epub 2010 Mar 1.
Interictal occipital epileptiform abnormalities have not been well characterized. The objective of this pilot study was to assess their significance in children.
A search was performed on the EEG database for the keywords "occipital", "spike", "sharp wave" and "epileptiform". Patients were divided into two groups based on the absence of all (group 1) or presence of any (group 2) of the following criteria: mental retardation, cerebral palsy, neurological deficits, abnormal MRI and/or intractable epilepsy. Special attention was given to the spike/sharp wave amplitude/duration and background slowing.
A total of 44 children (eight months to 15 years) were studied. Groups 1 and 2 were each composed of 22 children. Background slowing was more frequent in group 2 (10/22, 45%) compared to group 1 (1/22, 4.5%; p = 0.002). In group 2, 8/22 (36%) had spikes or sharp waves with amplitudes below 50 microV or above 150 microV with a positive predictive value of 89%, and a negative predictive value of 39%. Only 1/22 (4.5%) in group 1 had epileptiform activity outside of the 50-150 microV range.
The presence of very high or low-amplitude occipital epileptiform abnormalities or background slowing may be indicative of encephalopathy.
发作间期枕叶癫痫样异常尚未得到很好的描述。本研究旨在评估其在儿童中的意义。
在 EEG 数据库中搜索关键词“枕叶”、“棘波”、“尖波”和“癫痫样”。根据以下标准将患者分为两组：无（组 1）或存在（组 2）所有标准：智力障碍、脑瘫、神经功能缺损、异常 MRI 和/或难治性癫痫。特别注意棘波/尖波的幅度/持续时间和背景减慢。
共研究了 44 名儿童（8 个月至 15 岁）。组 1 和组 2 各由 22 名儿童组成。组 2（10/22，45%）比组 1（1/22，4.5%）背景减慢更常见（p=0.002）。在组 2 中，8/22（36%）的棘波或尖波幅度低于 50μV 或高于 150μV，阳性预测值为 89%，阴性预测值为 39%。在组 1 中，仅有 1/22（4.5%）的患者出现 50-150μV 范围之外的癫痫样活动。
非常高或低幅度的枕叶癫痫样异常或背景减慢可能提示脑病。
