多中心性Castleman病：科威特罕见病报告。

Multicentric Castleman disease: report of rare disease in Kuwait.

作者信息

Mohammad B A, Al-Brahim N, Kunjhibava S, Ahmad M, Ahmad M

机构信息

Department of Medicine, Al-Farwaniya Hospital, Kuwait.

出版信息

Gulf J Oncolog. 2009 Jul(6):48-50.

PMID:20194090

Abstract

UNLABELLED

We report a rare case of multicentric Castleman disease diagnosed in Kuwait. A 56-year-old man presented with fever of unknown origin and generalized lymphadenopathy. Laboratory investigations revealed mild anemia and polyclonal gammopathy. Bone marrow biopsy demonstrated 15% increase in plasma cells. Viral screenings including HIV were negative. Lymph node biopsy showed follicular hyperplasia with inter-follicular plasma cells infiltrate with a typical morphology of plasma cell variant of Castleman disease. The patient was treated with methyl-prednisone pulse therapy and showed good response.

CONCLUSION

Multicentric Castleman is a rare disease and clinicians and pathologists should be aware of it and should be considered in the differential diagnosis of fever of unknown origin and generalized lymphadenopathy.

摘要

未标注

我们报告了在科威特诊断出的一例罕见的多中心性Castleman病病例。一名56岁男性出现不明原因发热和全身淋巴结肿大。实验室检查显示轻度贫血和多克隆丙种球蛋白病。骨髓活检显示浆细胞增加15%。包括HIV在内的病毒筛查均为阴性。淋巴结活检显示滤泡增生，滤泡间有浆细胞浸润，具有Castleman病浆细胞变异型的典型形态。该患者接受了甲基泼尼松脉冲治疗，反应良好。