Kreft Andreas, Weber Achim, Springer Erik, Hess Georg, Kirkpatrick Charles James
Institut für Pathologie, Klinikum der Johannes Gutenberg Universität, Langenbeckstr. 1, 55101 Mainz, Germany.
Am J Surg Pathol. 2007 Mar;31(3):398-402. doi: 10.1097/01.pas.0000213382.40289.68.
Because bone marrow histology in multicentric Castleman disease in human immunodeficiency virus-negative patients is not well reported, we investigated sequential bone marrow biopsies of 3 affected human immunodeficiency virus-negative patients, of which one was human herpes virus 8 (HHV8)-positive. The histologic evaluation of the bone marrow revealed lymphoid follicles with regressed germinal centers in 1 patient. Another patient showed tumorlike but bland polyclonal plasmacytosis with large perivascular plasma cell clusters. The HHV8-positive patient revealed interstitial HHV8-positive cells accompanied by a mild plasmacytosis. The atypical lymphoid follicles could be regarded as a bone marrow manifestation of multicentric Castleman disease, whereas the plasmacytosis most likely is the result of excess interleukin 6 production. The presence of HHV8-positive cells within the bone marrow may indicate the dissemination of the virus in a compromised immune system.
由于人类免疫缺陷病毒阴性患者多中心Castleman病的骨髓组织学报道较少，我们对3例受影响的人类免疫缺陷病毒阴性患者进行了连续骨髓活检，其中1例为人类疱疹病毒8（HHV8）阳性。骨髓组织学评估显示，1例患者有生发中心退缩的淋巴滤泡。另1例患者表现为肿瘤样但温和的多克隆浆细胞增多，伴有大的血管周围浆细胞簇。HHV8阳性患者显示间质HHV8阳性细胞，伴有轻度浆细胞增多。非典型淋巴滤泡可被视为多中心Castleman病的骨髓表现，而浆细胞增多很可能是白细胞介素6产生过多的结果。骨髓内HHV8阳性细胞的存在可能表明病毒在受损免疫系统中的播散。
