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儿童多中心浆细胞型卡斯特曼病:诊断与治疗的难点

Multicentric plasma cell type of castleman disease in a child: difficulty in diagnosis and treatment.

作者信息

Karapinar Tuba H, Tüfekçi Özlem, Gözmen Salih, Yilmaz Sebnem, İrken Gülersu, Ören Hale

机构信息

Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.

出版信息

J Pediatr Hematol Oncol. 2013 Oct;35(7):e306-8. doi: 10.1097/MPH.0b013e31829cdd2a.

Abstract

Multicentric plasma cell variant of Castleman disease (CD) has rarely been reported and the optimal therapeutic approach is unknown, especially in childhood. In this case report, we discuss the case of a 7-year-old boy with multicentric plasma cell variant of CD, who presented with cervical lymphadenopathies, autoimmune hemolytic anemia, bone marrow insufficiency, pulmonary, renal, hepatic, and gastrointestinal involvement, emphasizing the difficulty in diagnosis and treatment approach.

摘要

卡斯特曼病(CD)的多中心浆细胞变异型鲜有报道,最佳治疗方法尚不清楚,尤其是在儿童患者中。在本病例报告中,我们讨论了一名7岁男孩患多中心浆细胞变异型CD的病例,该患儿表现为颈部淋巴结病、自身免疫性溶血性贫血、骨髓功能不全、肺部、肾脏、肝脏和胃肠道受累,强调了诊断和治疗方法上的困难。

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