Arora R, El-Hameed A A, Al Ajrawi T
Department of Pathology, Farwaniya Hospital, Farwaniya, Kuwait.
Gulf J Oncolog. 2009 Jul(6):51-5.
Dense lymphoplasmacytic infiltrate in tissues pose diagnostic challenge to pathologists. Presence of intracytoplasmic crystalline inclusions in plasma cells has been strongly linked with B- cell lymphoproliferative disorders, although isolated reactive cases are also reported. We reviewed the literature and present clinical, morphological and immunohistochemical findings in a polyp of the cervix. The polyp showed extensive plasma cell infiltrate with needle shaped and elongated intracytoplasmic inclusions in many of them. These cells were positive for CD 79alpha, CD 138, kappa and lambda light chain ( equal proportions) and IgG. They were negative for cytokeratin, desmin, CD 20, CD 68, and IgA. Immunoprofile, laboratory data and clinical follow up were consistent with reactive nature of the lesion. This case highlights the fact that the presence of intracytoplasmic crystalline inclusions should not be considered pathognomonic of B-cell lymphoproliferative disorder.
组织中密集的淋巴细胞浆细胞浸润给病理学家带来了诊断挑战。浆细胞内出现胞质内结晶性包涵体与B细胞淋巴增殖性疾病密切相关，尽管也有孤立的反应性病例报道。我们回顾了文献，并展示了一例宫颈息肉的临床、形态学和免疫组化结果。该息肉显示有广泛的浆细胞浸润，其中许多浆细胞含有针状和细长的胞质内包涵体。这些细胞CD 79α、CD 138、κ和λ轻链（比例相等）以及IgG呈阳性。它们细胞角蛋白、结蛋白、CD 20、CD 68和IgA呈阴性。免疫表型、实验室数据和临床随访结果与病变的反应性本质一致。该病例突出了这样一个事实，即胞质内结晶性包涵体的存在不应被视为B细胞淋巴增殖性疾病的特征性表现。
