Nakanaga M, Yasuda T, Tenjo E, Nadano D, Fujiki N, Kishi K
Department of Internal Medicine, Fukui Medical School, Japan.
Hum Biol. 1991 Apr;63(2):186-95.
Allele frequencies for human transferrin (TF) subtypes were determined using serum samples from Japanese subjects living in Fukui prefecture, Japan, and compared with other Japanese populations using isoelectric focusing (IEF) and immunoblotting. The application of IEF revealed considerable heterogeneity in the TF system, enhancing its potential value for anthropologic and genetic studies. So far, TF subtypes of about 27,000 Japanese individuals from 35 population groups have been analyzed to evaluate the degree of genetic variation at the TF locus. Possible geographic and biologic factors are discussed.
利用居住在日本福井县的日本受试者的血清样本，测定了人类转铁蛋白（TF）亚型的等位基因频率，并通过等电聚焦（IEF）和免疫印迹法与其他日本人群进行了比较。IEF的应用揭示了TF系统中存在相当大的异质性，增强了其在人类学和遗传学研究中的潜在价值。迄今为止，已对来自35个种群组的约27000名日本人的TF亚型进行了分析，以评估TF基因座的遗传变异程度。文中还讨论了可能的地理和生物学因素。
