Kamboh M I, Ferrell R E
Hum Hered. 1987;37(2):65-81. doi: 10.1159/000153680.
The application of isoelectric focussing (IEF) has revealed a large amount of heterogeneity in the human transferrin (TF) system and has enhanced its potential value in anthropological and genetic studies. The average heterozygosity has been elevated from 0.05, observed by conventional methods of electrophoresis, to 0.29 detected by IEF. So far approximately 30,000 individuals from 122 population groups have been analyzed for TF subtypes to evaluate the magnitude of genetic variation at the TF locus. Possible environmental and biological factors, which may be operating to maintain the TF polymorphism, are discussed.
等电聚焦（IEF）的应用揭示了人类转铁蛋白（TF）系统中存在大量的异质性，并提高了其在人类学和遗传学研究中的潜在价值。平均杂合度已从传统电泳方法观察到的0.05提高到IEF检测到的0.29。到目前为止，已经对来自122个人群组的约30000人进行了TF亚型分析，以评估TF基因座处遗传变异的程度。文中还讨论了可能维持TF多态性的环境和生物学因素。
