Tai Eric, Pollack Lori A, Townsend Julie, Li Jun, Steele C Brooke, Richardson Lisa C
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Atlanta, GA 30341, USA.
Arch Pediatr Adolesc Med. 2010 Mar;164(3):218-24. doi: 10.1001/archpediatrics.2010.4.
To examine differences in non-Hodgkin lymphoma (NHL) survival between young adults and children/adolescents.
Survival analysis using 13 Surveillance, Epidemiology, and End Results registries.
Cancer survival information from population-based cancer registries from 1992 through 2001.
A total of 2442 cases of NHL among children/adolescents (aged 0-19 years) and young adults (aged 20-29 years).
Differences in NHL survival between young adults and children.
Comparison of 5-year survival by constructing Kaplan-Meier survival curves and modeling 5-year survival with multivariate Cox proportional hazards.
Young adults were more likely to die compared with children/adolescents (hazard ratio = 2.06; 95% confidence interval, 1.65-2.56) even after accounting for NHL subtype and stage at diagnosis. Persons diagnosed with stage III disease (hazard ratio = 1.71; 95% confidence interval, 1.20-2.46) and stage IV disease (hazard ratio = 3.19; 95% confidence interval, 2.47-4.13) were more likely to die compared with persons diagnosed with stage I disease.
Being a young adult at diagnosis and having a higher stage of disease at diagnosis were associated with higher risk of death from NHL. Increasing survival with NHL is dependent on receiving appropriate cancer therapy. Therefore, efforts to address survival should include improving enrollment in clinical trials as well as increasing access to care.
研究青年人与儿童/青少年非霍奇金淋巴瘤（NHL）生存率的差异。
使用13个监测、流行病学和最终结果登记处进行生存分析。
1992年至2001年基于人群的癌症登记处的癌症生存信息。
共有2442例儿童/青少年（0至19岁）和青年（20至29岁）的NHL病例。
青年人与儿童NHL生存率的差异。
通过构建Kaplan-Meier生存曲线比较5年生存率，并使用多变量Cox比例风险模型对5年生存率进行建模。
即使在考虑NHL亚型和诊断分期后，青年人比儿童/青少年更有可能死亡（风险比=2.06；95%置信区间，1.65至2.56）。与诊断为I期疾病的人相比，诊断为III期疾病（风险比=1.71；95%置信区间，1.20至2.46）和IV期疾病（风险比=3.19；95%置信区间，2.47至4.13）的人更有可能死亡。
诊断时为青年人以及诊断时疾病分期较高与NHL死亡风险较高相关。提高NHL生存率取决于接受适当的癌症治疗。因此，提高生存率的努力应包括改善临床试验入组率以及增加获得医疗服务的机会。
