Department of Operative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
J Am Dent Assoc. 2010 Mar;141(3):285-96. doi: 10.14219/jada.archive.2010.0162.
In a single-center, double-masked, split-mouth-designed, clinical short-term trial, the authors assessed the clinical responses of teeth with dentin hypersensitivity (DH) after treating the teeth with one of three desensitizing agents across four weeks.
The authors selected 131 teeth with DH in 11 participants. The authors assessed DH of the teeth by using tactile stimuli and air stimuli and had the participants record the level of sensitivity by means of a visual analog scale (VAS). The authors then treated the teeth with one of three desensitizing agents (Pain-Free [Parkell, Edgewood, N.Y.], BisBlock [Bisco, Schaumburg, Ill.], Seal & Protect [Dentsply DeTrey, Konstanz, Germany]) that they applied according to the manufacturers' instructions. The authors used a split-mouth-designed study in which the teeth in different quadrants of the participants' mouths received different desensitizing agents. The authors also conducted DH evaluations at 10 minutes after treatment and at one, two, three and four weeks. The authors analyzed data statistically by using Mann-Whitney U and Kruskal-Wallis tests.
The results of the statistical analysis showed that all VAS scores at the posttreatment evaluation periods were reduced significantly compared with those at baseline (P<.05). More teeth were sensitive to air stimuli than to tactile stimuli. The mean VAS scores for DH in the mandibular teeth were significantly higher than for those in maxillary teeth immediately after treatment (for tactile stimuli) and two weeks after the first application (for air stimuli) (P<.05)
All three desensitizing agents were effective in relieving DH up to four weeks, independent of their application procedures. There was, however, a significant reduction in mean sensitivity scores of teeth that had been treated with Seal & Protect and Pain-Free compared with those of BisBlock at weeks two, three and four.
The study results should be considered with caution, as it is not clear how many of the pain relief effects were related to the natural desensitization of teeth over time.
在一项为期四周的单中心、双盲、分口设计的临床短期试验中，作者评估了三种脱敏剂治疗牙齿牙本质敏感症（DH）后牙齿的临床反应。
作者选择了 11 名参与者的 131 颗有 DH 的牙齿。作者通过触觉刺激和空气刺激评估牙齿的 DH，并让参与者通过视觉模拟量表（VAS）记录敏感度水平。然后，作者根据制造商的说明用三种脱敏剂（Pain-Free[Parkell，Edgewood，NY]、BisBlock[Bisco，Schaumburg，Ill.]、Seal & Protect[Dentsply DeTrey，Konstanz，Germany]）中的一种治疗牙齿。作者使用分口设计研究，参与者口腔不同象限的牙齿接受不同的脱敏剂。作者还在治疗后 10 分钟和 1、2、3、4 周进行 DH 评估。作者通过 Mann-Whitney U 和 Kruskal-Wallis 检验对数据进行统计学分析。
统计分析结果表明，所有治疗后评估期的 VAS 评分均较基线显著降低（P<.05）。更多的牙齿对空气刺激敏感，而不是触觉刺激。下颌牙的 DH 平均 VAS 评分在治疗后即刻（触觉刺激）和第一次应用后两周（空气刺激）明显高于上颌牙（P<.05）。
三种脱敏剂在 4 周内均可有效缓解 DH，与应用程序无关。然而，在第二、第三和第四周，用 Seal & Protect 和 Pain-Free 治疗的牙齿的平均敏感度评分与 BisBlock 相比有显著降低。
研究结果应谨慎考虑，因为尚不清楚有多少缓解疼痛的效果与牙齿随时间自然脱敏有关。
