AlQahtani Saad Mohammed, Nagate Raghavendra Reddy, Al-Ahmari Manae Musa Musleh, Magbol Mohammad Al, Gokhale Shankar T, Tikare Shreyas, Chaturvedi Saurabh
Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Gels. 2023 Jun 12;9(6):483. doi: 10.3390/gels9060483.
Propolis is a natural resinous substance collected by honeybees, chiefly from buds and the leaves, branches, and bark of trees. Its role as a wound-healing gel has been studied, but the use of a propolis hydrogel in the treatment of dentinal hypersensitivity has not been evaluated. Dentin hypersensitivity (DH) is commonly treated via iontophoresis using fluoridated desensitizers. The aim of the present study was to compare and evaluate the effects of a 10% propolis hydrogel, 2% sodium fluoride (NaF), and 1.23% acidulated phosphate fluoride (APF) when used in conjunction with iontophoresis for the treatment of cervical dentin hypersensitivity (DH).
Systemically healthy patients complaining of DH were selected for this single-centre, parallel, double-blind randomized clinical trial. Three substances were selected as desensitizers for study in the present trial: a 10% propolis hydrogel, 2% sodium fluoride, and 1.23% acidulated phosphate fluoride, all in conjunction with iontophoresis. Any decrease in DH following the application of specific stimuli was assessed at baseline, before and after application, on the 14th day following use, and on the 28th day following the intervention.
Intra-group comparisons show diminished values of DH at maximum post-op follow-up intervals which were significantly trimmed down from the baseline ( < 0.05). The 2% NaF demonstrated a significant reduction in DH over 1.23% APF and the 10% propolis hydrogel ( < 0.05). However, there was no statistically significant difference in the mean difference between the APF and propolis hydrogel groups assessed via tactile, cold, and air tests ( > 0.05).
All three desensitizers have proved to be useful when used in conjugation with iontophoresis. Within the limitations of this study, a 10% propolis hydrogel can be used as a naturally occurring alternative to commercially available fluoridated desensitizers.
蜂胶是蜜蜂采集的一种天然树脂物质，主要来源于芽以及树木的叶子、树枝和树皮。其作为伤口愈合凝胶的作用已得到研究，但蜂胶水凝胶在治疗牙本质过敏方面的应用尚未得到评估。牙本质过敏症（DH）通常通过使用含氟脱敏剂的离子导入法进行治疗。本研究的目的是比较和评估10%蜂胶水凝胶、2%氟化钠（NaF）和1.23%酸性磷酸氟（APF）与离子导入法联合使用时治疗颈部牙本质过敏症（DH）的效果。
选择主诉患有DH的全身健康患者进行这项单中心、平行、双盲随机临床试验。在本试验中选择三种物质作为脱敏剂进行研究：10%蜂胶水凝胶、2%氟化钠和1.23%酸性磷酸氟，均与离子导入法联合使用。在基线、应用前和应用后、使用后第14天以及干预后第28天，评估在施加特定刺激后DH的任何降低情况。
组内比较显示，术后最大随访间隔时DH值降低，与基线相比显著降低（<0.05）。2% NaF在降低DH方面比1.23% APF和10%蜂胶水凝胶表现出更显著的效果（<0.05）。然而，通过触觉、冷和空气测试评估，APF组和蜂胶水凝胶组之间的平均差异无统计学意义（>0.05）。
所有三种脱敏剂与离子导入法联合使用时均被证明是有效的。在本研究的局限性内，10%蜂胶水凝胶可作为市售含氟脱敏剂的天然替代品使用。
