Melbourne Neuropsychiatry Centre, c/o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia.
Br J Psychiatry. 2010 Mar;196(3):206-11. doi: 10.1192/bjp.bp.109.069732.
Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear.
To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis.
We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls.
Those at risk of psychosis had significantly smaller superior temporal gyri at baseline compared with controls bilaterally, without any prominent subregional effect; however, there was no difference between those who did and did not subsequently develop psychosis.
Our findings indicate that grey matter reductions of the superior temporal gyrus are present before psychosis onset, and are not due to medication, but these baseline changes are not predictive of transition to psychosis.
精神分裂症患者的颞上回形态异常一直有报道，但它们的发生时间尚不清楚。
确定个体是否在精神病发作前出现颞上回变化。
我们使用磁共振成像检查了 97 名抗精神病药物治疗前处于精神病超高风险的个体、其中 31 名随后发展为精神病、66 名未发展为精神病的个体以及 42 名对照者的颞上回及其亚区（极外侧、Heschl 回、颞上回、前侧和后侧）的灰质体积。
与对照组相比，精神病风险个体双侧颞上回在基线时明显较小，没有明显的亚区效应；然而，随后是否发展为精神病的个体之间没有差异。
我们的研究结果表明，颞上回灰质减少在精神病发作前存在，并且不是由于药物引起的，但这些基线变化不能预测向精神病的转变。
