Post Robert M, Luckenbaugh David A, Leverich Gabriele S, Altshuler Lori L, Frye Mark A, Suppes Trisha, Keck Paul E, McElroy Susan L, Nolen Willem A, Kupka Ralph, Grunze Heinz, Walden Joerg
Department of Psychiatry, George Washington University, Washington, DC, USA.
Br J Psychiatry. 2008 Feb;192(2):150-1. doi: 10.1192/bjp.bp.107.037820.
The relative incidence of childhood-onset bipolar illness in the USA compared with that in Europe is controversial. We examined this issue in more than 500 out-patients (average age 42 years) with bipolar illness who reported age at onset of first episode, family history, and childhood physical or sexual abuse. Childhood or adolescent onset of bipolar illness was reported by 61% of those in the US cohort but by only 30% of those in The Netherlands or Germany. In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration.
与欧洲相比，美国儿童期起病的双相情感障碍的相对发病率存在争议。我们对500多名双相情感障碍门诊患者（平均年龄42岁）进行了研究，这些患者报告了首次发作的年龄、家族史以及童年期身体或性虐待情况。美国队列中有61%的患者报告双相情感障碍起病于儿童期或青少年期，而荷兰或德国队列中这一比例仅为30%。在美国，童年期逆境以及情感障碍的遗传/家族风险的发生率也高出一倍。这些发现值得重复验证和进一步探索。
