Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
Hum Exp Toxicol. 2010 Oct;29(10):845-50. doi: 10.1177/0960327110363441. Epub 2010 Mar 1.
Monocrotophos is an organophosphate pesticide used in agriculture to control insect pests. Changes in performance and haematological parameters (such as packed cell volume, white blood cells, neutrophils, eosinophils and lymphocytes) were used to assess the effect of the pesticide on rats chronically exposed to 12.5 parts per million (ppm), 25 ppm, 50 ppm, 100 ppm and 200 ppm for 10 days, while the control rats were placed on borehole water. Administration of the pesticide to the animals resulted in several physical deteriorations including appearance and agility. A significant reduction (p < .05) was observed in the weight gained by rats while the liver-to-body weight ratio increased significantly (p < .05) as the level of exposure to monocrotophos increased. Whereas packed cell volume, white blood cells and lymphocytes increased significantly (p < .05), neutrophils and eosinophils counts reduced significantly (p < .05) as the concentration of monocrotophos in the drinking water increased. Overall, the data indicated that exposure to monocrotophos portends serious consequences on the performance and haematological parameters of rats.
久效磷是一种用于农业控制虫害的有机磷农药。通过检测性能和血液学参数（如红细胞压积、白细胞、中性粒细胞、嗜酸性粒细胞和淋巴细胞）的变化来评估这种农药对老鼠的影响。老鼠在暴露于 12.5ppm、25ppm、50ppm、100ppm 和 200ppm 的久效磷 10 天后，作为对照组的老鼠则被放置在钻孔水中。给动物施用这种农药会导致多种身体恶化，包括外观和敏捷性。老鼠的体重增长显著减少（p <.05），而随着暴露于久效磷水平的增加，肝体比显著增加（p <.05）。然而，随着饮用水中久效磷浓度的增加，红细胞压积、白细胞和淋巴细胞显著增加（p <.05），而中性粒细胞和嗜酸性粒细胞计数则显著减少（p <.05）。总的来说，数据表明，接触久效磷会对老鼠的性能和血液学参数产生严重影响。
