Patrick-Iwuanyanwu Kingsley C, Nkpaa Kpobari W
Department of Biochemistry (Toxicology unit), University of Port Harcourt, Rivers State, Nigeria.
J Xenobiot. 2015 Nov 10;5(1):5369. doi: 10.4081/xeno.2015.5369. eCollection 2015 Apr 29.
The indiscriminate administration of ready-to-use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters (CB) - a polyherbal formula prepared with and on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia.
由于即食草药制剂存在潜在健康风险，其随意使用已成为一个主要问题。该研究调查了苦味剂类（CB）——一种由[具体成分1]和[具体成分2]制备的多草药配方——对雄性Wistar白化大鼠血清电解质和血液学参数的影响。将两种剂量（500和1000毫克/千克）的多草药药物口服给予雄性Wistar白化大鼠，持续9周。结果表明，与对照组相比，给予500和1000毫克/千克体重的CB后，钠和氯的水平显著升高。然而，钾和碳酸氢盐的水平显著降低。研究结果还表明，与对照组相比，雄性Wistar白化大鼠的血红蛋白（Hb）、红细胞压积（PCV）、红细胞（RBC）和血小板水平等血液学参数显著（P≤0.05）降低。本研究中实验大鼠观察到的Hb、PCV、RBC和血小板浓度显著降低表明，CB可能对红细胞生成有不利影响。因此，这些观察结果表明，长期给予CB可能会导致肾脏疾病和贫血。
