Keizer Ron J, Beijnen Jos H, Baas Paul
Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands.
J Oncol Pharm Pract. 2011 Sep;17(3):270-3. doi: 10.1177/1078155210363166. Epub 2010 Mar 1.
In this case report, we describe a patient with bronchoalveolar carcinoma that experienced severe bronchorrhea and dyspnea after inhalation of N-acetylcysteine. The adverse reactions occurred both after oral and nebulized administration of N-acetylcysteine, resulting in severe dyspnea and the feeling of 'drowning'. Bronchorrhea has previously been reported as an uncommon but serious complication of bronchoalveolar carcinoma. We strongly suspect the administration of N-acetylcysteine to be implicated, as the complications occurred immediately after administration of this drug. As the patient suffered from hyperhomocysteinemia, we speculate that an additive or synergistic interaction with homocysteine may have been involved as well.
在本病例报告中，我们描述了一名支气管肺泡癌患者，其在吸入N-乙酰半胱氨酸后出现了严重的支气管分泌过多和呼吸困难。口服和雾化吸入N-乙酰半胱氨酸后均出现了不良反应，导致严重的呼吸困难和“溺水”感。支气管分泌过多此前已被报道为支气管肺泡癌一种罕见但严重的并发症。我们强烈怀疑N-乙酰半胱氨酸的使用与之有关，因为这些并发症在使用该药物后立即出现。由于该患者患有高同型半胱氨酸血症，我们推测可能也涉及与同型半胱氨酸的相加或协同相互作用。
