铜绿假单胞菌外排泵、OprD 孔蛋白、AmpCβ-内酰胺酶与囊性纤维化患者分离株的多重耐药性。
Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
机构信息
Centre for Infections, Health Protection Agency, London, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2219-24. doi: 10.1128/AAC.00816-09. Epub 2010 Mar 1.
Abstract
Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance. A specific combination of mexR, nalC, and nalD mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated mexA.
摘要
对 25 株来自囊性纤维化患者的铜绿假单胞菌分离株进行了 ampC、oprD、mexA、mexC、mexE 和 mexX 的表达研究，其中包括 14 株利物浦流行株。β-内酰胺耐药与过度表达的 mexA 或 ampC 和 oprD 减少有关。11 株利物浦株分离株中存在 mexR、nalC 和 nalD 突变的特定组合，其中 7 株上调了 mexA。
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