Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.
Plast Reconstr Surg. 2010 Mar;125(3):944-52. doi: 10.1097/PRS.0b013e3181cb6589.
Many clinical trials have shown the effectiveness of platelet releasate on chronic wound healing, but large volumes of blood must be aspirated from patients and a platelet separator is required. Moreover, in the case of using homologous platelets, time and effort are needed to locate a suitable donor, and the donor's blood sample must be tested for a history of infectious disease. The current study was undertaken to evaluate the effect of a straightforward method using a blood bank platelet concentrate in treating diabetic foot ulcers.
Fifty-two patients with diabetic foot ulcers were treated using a blood bank platelet concentrate. A control treatment (i.e., treatment with topical fibrinogen and thrombin) was performed on 48 patients. Twelve weeks after treatment, the percentage of complete healing, mean healing time, percentage of wound shrinkage, and patient satisfaction were compared.
Complete wound healing was achieved in 79 percent of the blood bank platelet concentrate-treated group and 46 percent of the control group (p < 0.05). The times required for complete healing were 7.0 +/- 1.9 and 9.2 +/- 2.2 weeks in the blood bank platelet concentrate-treated and control groups, respectively (p < 0.05). The degrees of wound shrinkage were 96.3 +/- 7.8 and 81.6 +/- 19.7 percent for the treated and control groups, respectively (p < 0.05). Patient satisfaction with the blood bank platelet concentrate treatment yielded better results than the control method (mean score, 7.6 +/- 1.6 and 5.3 +/- 1.4, respectively; p < 0.05). No adverse events related to the study treatment occurred.
Treatment of diabetic foot ulcers using a blood bank platelet concentrate showed results superior to control treatment. A blood bank platelet concentrate offers a simple and effective treatment for diabetic foot ulcers.
许多临床试验已经证明了血小板释放物在慢性伤口愈合方面的有效性，但需要从患者中抽取大量血液并使用血小板分离机。此外，在使用同源血小板的情况下，需要时间和精力来寻找合适的供体，并且必须测试供体的血液样本是否有传染病史。本研究旨在评估使用血库血小板浓缩物治疗糖尿病足溃疡的简单方法的效果。
52 例糖尿病足溃疡患者采用血库血小板浓缩物治疗。48 例患者采用对照组（即局部纤维蛋白原和凝血酶治疗）。治疗 12 周后，比较完全愈合率、平均愈合时间、创面缩小率和患者满意度。
血库血小板浓缩物治疗组完全愈合率为 79%，对照组为 46%（p<0.05）。血库血小板浓缩物治疗组和对照组完全愈合所需时间分别为 7.0±1.9 和 9.2±2.2 周（p<0.05）。治疗组和对照组的创面缩小率分别为 96.3±7.8%和 81.6±19.7%（p<0.05）。患者对血库血小板浓缩物治疗的满意度优于对照组（平均评分分别为 7.6±1.6 和 5.3±1.4，p<0.05）。未发生与研究治疗相关的不良事件。
使用血库血小板浓缩物治疗糖尿病足溃疡的效果优于对照组。血库血小板浓缩物为糖尿病足溃疡提供了一种简单有效的治疗方法。
