Division of Gastroenterology, Department of Medicine, University of Gaziantep, Gaziantep, Turkey.
Panminerva Med. 2009 Dec;51(4):205-13.
Metabolic syndrome comprises a cluster of risk factors that predispose to mainly cardiovascular disease and its complications. It is also closely associated with liver steatosis and fibrosis. Metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease, are very prevalent both in general population and also pre- and post-transplantation setting. Important life-style changes and immunosuppressive treatment after liver transplantation seem to have significant effects for the development of the Metabolic syndrome: increased risks for liver transplant recipients and challenges for successful treatment outcomes. Its association with major vascular events and negative effects on progression of fibrosis in recurrent hepatitis C after transplantation have been major concerns for transplant patients in recent years. There is no standard therapeutic approach to these patients, and well-designed prospective studies are certainly needed to define management strategy. Until such specific data become available, early aggressive risk factor modification should be aimed and each component of the syndrome should be cared separately.
代谢综合征是一组易导致主要心血管疾病及其并发症的风险因素。它还与肝脂肪变性和纤维化密切相关。代谢综合征及其肝脏表现，非酒精性脂肪性肝病，在普通人群以及移植前和移植后环境中都非常普遍。肝移植后重要的生活方式改变和免疫抑制治疗似乎对代谢综合征的发展有显著影响：增加了肝移植受者的风险，并对丙型肝炎复发纤维化的治疗结果产生挑战。近年来，它与主要血管事件的关联以及对移植后丙型肝炎纤维化进展的负面影响一直是移植患者关注的主要问题。这些患者没有标准的治疗方法，需要进行精心设计的前瞻性研究来确定管理策略。在获得这些特定数据之前，应针对早期积极的危险因素进行修正，并分别处理综合征的每个组成部分。
