Păuşescu E, Chirvasie R, Popescu M V, Teodosiu T
Physiologie. 1977 Oct-Dec;14(4):283-9.
The total amounts of cyclic AMP (cAMP), prostaglandin E1 (PGE1) and prostaglandin F2alpha (PGF2alpha) in cerebra have been measured in rats, at constant intervals, up to 18 days after whole body exposure to either a unique moderate dose (500 rads) or a unique lethal dose (750 rads) of cobalt-60 gamma-radiation. The experimental findings indicate that this radiation (i) results in an abrupt short-lasting increase in the amount of cerebral cAMP after a 500 rad-irradiation and a progressive long-lasting increase in its amount after a 750 rad-irradiation, and (ii) induces no change in the normally, existing correlation between cerebral PGE1 and cAMP, but affects deeply the normally existing correlation between cerebral PGF2alpha and cAMP. These biochemical alterations generally parallel the evolution of the radiation-induced brain edema.
在大鼠全身暴露于单一中等剂量（500拉德）或单一致死剂量（750拉德）的钴-60γ辐射后，每隔一定时间测量其大脑中环状单磷酸腺苷（cAMP）、前列腺素E1（PGE1）和前列腺素F2α（PGF2α）的总量，直至18天。实验结果表明，这种辐射（i）在500拉德照射后导致大脑cAMP量突然短暂增加，在750拉德照射后导致其量逐渐持久增加，并且（ii）不改变大脑PGE1与cAMP之间正常存在的相关性，但深刻影响大脑PGF2α与cAMP之间正常存在的相关性。这些生化改变通常与辐射诱导的脑水肿的发展情况平行。
