小窝蛋白在微生物致病机制中的作用不断扩展。
The expanding roles of caveolin proteins in microbial pathogenesis.
作者信息
Zaas David W, Swan Zachary, Brown Bethany J, Wright Jo Rae, Abraham Soman N
机构信息
Duke University Medical Center; Durham, NC, USA.
出版信息
Commun Integr Biol. 2009 Nov;2(6):535-7. doi: 10.4161/cib.2.6.9259.
Abstract
Caveolin proteins have been implicated in a wide range of cellular functions including lipid raft mediated endocytosis and regulation of cell signaling cascades. Recent discoveries have shown that these proteins are involved not only in regulating these homeostatic cellular functions, but also in the host response to a wide range of different infections. Both caveolin-1 and 2 have been shown to play important roles in pathogen uptake. While caveolin-1 is the most well studied member of this family, a growing body of evidence has now recognized the role of caveolin-2 in these host pathogen interactions and novel host defense mechanisms.
摘要
小窝蛋白已被证明参与多种细胞功能，包括脂筏介导的内吞作用和细胞信号级联反应的调节。最近的发现表明，这些蛋白质不仅参与调节这些细胞稳态功能，还参与宿主对多种不同感染的反应。小窝蛋白-1和小窝蛋白-2都已被证明在病原体摄取中起重要作用。虽然小窝蛋白-1是该家族中研究最深入的成员，但现在越来越多的证据认识到小窝蛋白-2在这些宿主-病原体相互作用和新型宿主防御机制中的作用。
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