Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-476, Korea.
Macromol Biosci. 2010 Jun 11;10(6):563-79. doi: 10.1002/mabi.200900402.
Injectable biodegradable copolymer hydrogels, which exhibit a sol-gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site-specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature-sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature-sensitive polymers such as sulfamethazine-, poly(beta-amino ester)-, poly(amino urethane)-, and poly(amidoamine)-based polymers. The advantages of pH/temperature-sensitive polymers over simple temperature-sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.
可注射的生物可降解共聚物水凝胶，可响应外部刺激（如温度变化或 pH 值和温度的变化（pH/温度））发生溶胶-凝胶相转变，在生物医药和制药应用中找到了许多用途，如药物输送、细胞生长和组织工程。这些水凝胶可以用于简单的药物制剂，通过将水凝胶与药物、蛋白质或细胞混合来制备。这些制剂可以通过在特定部位控制释放行为以简单的方式进行给药，并且水凝胶与生物系统相容。这篇综述将提供最近在生物可降解温度敏感聚合物方面的进展的概述，包括聚酯、聚膦嗪、多肽和壳聚糖，以及 pH/温度敏感聚合物，如磺胺嘧啶基、聚（β-氨基酯）、聚（氨基甲酸酯）和聚（酰胺胺）基聚合物。还讨论了 pH/温度敏感聚合物相对于简单的温度敏感聚合物的优势。提供了对可注射生物可降解水凝胶未来的展望。
