Maccabee P J, Amassian V E, Cracco R Q, Cracco J B, Eberle L, Rudell A
Department of Neurology, State University of New York, Brooklyn 11203.
J Clin Neurophysiol. 1991 Jan;8(1):38-55. doi: 10.1097/00004691-199101000-00006.
The magnetic coil (MC) is a unique probe that can be used to elucidate basic neurophysiological mechanisms in humans. Either by excitation or inhibition of responding neural elements, we have been able to investigate: (1) the distribution of the electric field induced within isotropic and anisotropic volume conductors by round and figure-eight MCs; (2) the theoretical relationship between electric field distribution and excitation of distal peripheral nerve, nerve root, cranial nerve, and motor cortex; (3) the effect of focal MC stimulation of motor and visual systems; (4) perturbation of sequential digit movements by MC stimulation of human premotor cortex; (5) activation of frontal motor areas related to speech; (6) elicitation of a sense of movement in an ischemic paralyzed limb by focal MC cortical stimulation; and (7) the effect of stimulation of the human visual system to (a) suppress and unmask visual perception using single MC stimuli and (b) prolong visual suppression using short trains of MC stimuli. In the future, prolongation of MC action by using repetitive stimuli should be useful in further investigating functions concerned with language, speech, and cognition.
磁线圈（MC）是一种独特的探头，可用于阐明人类基本的神经生理机制。通过激发或抑制反应性神经元件，我们能够研究：（1）圆形和8字形MC在各向同性和各向异性体积导体中感应的电场分布；（2）电场分布与远端周围神经、神经根、颅神经和运动皮层兴奋之间的理论关系；（3）MC对运动和视觉系统的局灶性刺激的影响；（4）MC刺激人类运动前皮层对连续数字运动的干扰；（5）与言语相关的额叶运动区的激活；（6）MC皮层局灶性刺激在缺血性瘫痪肢体中引发运动感觉；以及（7）刺激人类视觉系统对（a）使用单个MC刺激抑制和揭示视觉感知以及（b）使用短串MC刺激延长视觉抑制的影响。未来，使用重复刺激延长MC作用对于进一步研究与语言、言语和认知相关的功能应该是有用的。
