通过双 C-H 键活化合成氮杂稠合多环喹啉。
Synthesis of aza-fused polycyclic quinolines via double C-H bond activation.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, 17/3 South Renmin Road, Chengdu, 610041, PR China.
出版信息
Chemistry. 2012 Jul 16;18(29):8896-900. doi: 10.1002/chem.201201207. Epub 2012 Jun 19.
Simple but efficient: Aza-fused polycyclic quinolines were efficiently assembled through rhodium(III)-based direct double C-H activation of N-aryl azoles followed by cyclization with alkynes without heteroatom-assisted chelation. Copper(II) acetate, aside from acting as an oxidant, could also play an important role in the C-H activation process.
简单高效
通过铑(III)催化的 N-芳基氮唑的直接双 C-H 活化，随后与炔烃环化，无需杂原子辅助螯合，高效地构建了含氮并环的喹啉衍生物。醋酸铜除了作为氧化剂外，还可以在 C-H 活化过程中发挥重要作用。
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