旧药新用：新生儿糖尿病与磺酰脲类药物
New uses for old drugs: neonatal diabetes and sulphonylureas.
机构信息
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.
出版信息
Cell Metab. 2010 Mar 3;11(3):179-81. doi: 10.1016/j.cmet.2010.02.004.
PMID:20197050
Abstract
The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy.
摘要
研究发现，新生儿糖尿病是由 K(ATP) 通道功能获得性突变引起的，这使得许多患者能够从胰岛素切换到口服磺脲类药物。在这里，我回顾了这种治疗方式改变的分子、生理和临床特征。
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