Sunol J, Greck T, Hédon B, Seignalet J, Lete E, Eid J, Mares P, Benos P, Boulot P, Audibert F
Services de Gynécologie-Obstétrique, Faculté de Médecine Montpellier-Nimes.
J Gynecol Obstet Biol Reprod (Paris). 1991;20(1):33-40.
81 patients who had consulted for infertility, of whom 26 had recurrent spontaneous abortions (RSA), 28 unexplained infertility (UI), and 27 with difficulties for implantation following in vitro fertilization (IVF) were tested by a cross-match for the presence of the partner's lymphocyte antibodies. When the result was negative, leucocyte transfusions were carried out (200 million of the partner's lymphocytes in 3 successive injections at intervals of one month). Positive antipaternal cytotoxic antibodies were found in 81% of cases. There was, however, no benefit in groups of unexplained infertility or implantation difficulties. In the RSA group there was a 50% recurrence of spontaneous abortions.
81名因不孕前来咨询的患者接受了针对伴侣淋巴细胞抗体存在情况的交叉配型检测，其中26人有复发性自然流产（RSA），28人患有不明原因不孕（UI），27人在体外受精（IVF）后存在着床困难。当结果为阴性时，进行白细胞输注（每次注射2亿个伴侣的淋巴细胞，连续3次，间隔1个月）。81%的病例中发现了阳性抗父本细胞毒性抗体。然而，在不明原因不孕或着床困难组中未发现有益效果。在RSA组中，自然流产复发率为50%。
