Kuhn U, Campo R, Hinney B, Neumeyer H, Criel A, Gordts S, Kuhn W
Abteilung für Geburtshilfe und Perinatale Medizin, Universität Essen.
Z Geburtshilfe Perinatol. 1993 Sep-Oct;197(5):209-14.
In a two-centre prospective study 20 patients with a history of unsuccessful sterility treatment underwent immunization with paternal lymphocytes to improve the pregnancy rate in the subsequent therapeutic AIH or IVF/ET cycle. Unsuccessful sterility treatment was defined as no pregnancy after 8 properly monitored AIH cycles and at least one diagnostic IVF/ET or more than 3 IVF with transfer of 3 embryos. After successful immunization expressed by the induction of Fc-receptor blocking antibodies 10/20 patients became pregnant. Nine of these patients delivered healthy children, one patient experienced a first trimester abortion. A successful second pregnancy occurred in 6 of these patients. No significant correlation between the previous history and pregnancy success could be found, except a slight advantage for patients with a history other than tubal sterility. There were no differences in the anamnestic data as well as in the success rate between the two independent centres Göttingen and Leuven (10 patients each). These data suggest, that adjuvant immunotherapy might improve markedly the pregnancy rates in selected cases of sterility.
在一项双中心前瞻性研究中，20例有不育治疗失败史的患者接受了父方淋巴细胞免疫，以提高随后治疗性人工授精或体外受精/胚胎移植周期的妊娠率。不育治疗失败定义为在8个经过适当监测的人工授精周期后未妊娠，且至少有一次诊断性体外受精/胚胎移植或3次以上体外受精并移植3个胚胎。在通过诱导Fc受体阻断抗体表示免疫成功后，20例患者中有10例怀孕。其中9例患者分娩出健康婴儿，1例患者在孕早期流产。这些患者中有6例成功再次妊娠。除了输卵管性不育以外的其他病史患者有轻微优势外，既往病史与妊娠成功之间未发现显著相关性。在两个独立中心哥廷根和鲁汶（各10例患者）之间，既往数据以及成功率均无差异。这些数据表明，辅助免疫疗法可能会显著提高某些不育病例的妊娠率。
