Opinel P, Le Hors H, Tramier D, Inguimbert M, Audibert M, Cassin D
Service de Gynécologie-Obsétrique du Centre Hospitalier, Aix-en Provence.
J Gynecol Obstet Biol Reprod (Paris). 1991;20(1):60-2.
We report a case of hyperestrogenisation which showed itself by the presence of a haematocolpometra in an elderly lady which could be attributed to prolonged and continuous treatment with Promestriene cream. Haematocolpometra is due to intra-uterine haemorrhage (itself due to hyperplastic endometrial polyps) with vaginal stenosis caused by vaginal atrophy that existed before local treatment was started. The Pomestriene is an estrogenic substance which works locally and does not seem to cause much in the way of general effects when used for short courses. If when it is used in large doses over a prolonged period of time, however, it is necessary to look for generalised hyperestrogenisation. Further studies are needed to confirm these finding.
我们报告了一例雌激素过多症病例，该病例表现为一名老年女性出现血性阴道积脓，这可能归因于长期持续使用普罗雌烯乳膏治疗。血性阴道积脓是由于子宫内出血（其本身是由增生性子宫内膜息肉引起），以及在开始局部治疗之前就已存在的阴道萎缩导致的阴道狭窄。普罗雌烯是一种雌激素物质，局部起作用，短期使用时似乎不会引起太多全身影响。然而，如果长期大剂量使用，就需要留意全身性雌激素过多症。需要进一步研究来证实这些发现。
