Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Eur J Obstet Gynecol Reprod Biol. 2010 Jun;150(2):157-9. doi: 10.1016/j.ejogrb.2010.02.013. Epub 2010 Mar 1.
The aim of this study was to investigate the prognosis in future IVF cycles of patients with empty follicle syndrome (EFS).
EFS cases and their future cycles were reviewed. Clinical pregnancy rate per started cycle was taken as the primary outcome in assessing the future outcome in IVF treatment cycles.
A total of 3023 patients underwent 5238 IVF treatment cycles. Twenty-six patients (1%) had a total of 58 (1%) cycles of EFS. Thirteen women went through 32 further IVF treatment cycles following the diagnosis of EFS, yielding only two clinical pregnancies, giving a clinical pregnancy rate of 6.25% per started cycle. In addition, four patients had recurrence in a total of 15 cycles.
The occurrence of EFS will indicate poor IVF success in subsequent IVF cycles. Patients with "genuine EFS" should be counselled about the outcome of their future IVF cycles.
本研究旨在探讨空卵泡综合征（EFS）患者未来体外受精（IVF）周期的预后。
回顾 EFS 病例及其未来周期。以每个启动周期的临床妊娠率作为评估 IVF 治疗周期未来结局的主要指标。
共有 3023 名患者接受了 5238 个 IVF 治疗周期。26 名患者（1%）共有 58 个周期（1%）出现 EFS。13 名女性在诊断为 EFS 后经历了 32 个进一步的 IVF 治疗周期，仅获得了 2 次临床妊娠，每个启动周期的临床妊娠率为 6.25%。此外，4 名患者在总共 15 个周期中出现了复发。
EFS 的发生表明随后的 IVF 周期中 IVF 成功率较低。应向“真正的 EFS”患者告知其未来 IVF 周期的结局。
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