Department of Biology, Duke University, Durham, North Carolina 27708, USA.
RNA. 2010 Apr;16(4):664-6. doi: 10.1261/rna.1871310. Epub 2010 Mar 2.
Small nucleolar ribonucleoproteins (snoRNPs) are widely studied and characterized as guide RNAs for sequence-specific 2'-O-ribose methylation and psuedouridylation of ribosomal RNAs. In addition, snoRNAs have also been shown to interact with some tRNAs and direct alternative splicing in mRNA biogenesis. Recent advances in bioinformatics have resulted in new algorithms able to rapidly identify noncoding RNAs generally and snoRNAs specifically in genomic and metagenomic sequences, resulting in a rapid increase in the number and diversity of identified snoRNA sequences. The snoRNP database is a web-based collection of snoRNA and snoRNA-associated protein sequences from a wide range of species. The database currently contains 8994 snoRNA sequences from Bacteria, Archaea, and Eukaryotes and 589 snoRNA-associated protein sequences. The snoRNP database can be found at: http://evolveathome.com/snoRNA/snoRNA.php.
小核仁核糖核蛋白（snoRNPs）是广泛研究和表征的核糖体 RNA 序列特异性 2'-O-核糖甲基化和假尿嘧啶化的 guide RNA。此外，snoRNAs 还被证明与一些 tRNAs 相互作用，并在 mRNA 生物发生中指导选择性剪接。生物信息学的最新进展产生了新的算法，能够快速识别基因组和宏基因组序列中的非编码 RNA 一般和 snoRNAs 特定，导致鉴定的 snoRNA 序列数量和多样性迅速增加。snoRNP 数据库是一个基于网络的 snoRNA 和 snoRNA 相关蛋白序列的集合，来自广泛的物种。该数据库目前包含来自细菌、古菌和真核生物的 8994 个 snoRNA 序列和 589 个 snoRNA 相关蛋白序列。snoRNP 数据库可在以下网址找到：http://evolveathome.com/snoRNA/snoRNA.php。
