Irimie Alexandra Iulia, Zimta Alina-Andreea, Ciocan Cristina, Mehterov Nikolay, Dudea Diana, Braicu Cornelia, Berindan-Neagoe Ioana
Department of Prosthetic Dentistry and Dental Materials, Division Dental Propaedeutic, Aesthetic, "IuliuHatieganu" University of Medicine and Pharmacy, Cluj-Napoca, 23 Marinescu Street, 40015 Cluj-Napoca, Romania.
MEDFUTURE-Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu-Hatieganu, 23 Marinescu Street, 40015 Cluj-Napoca, Romania.
Genes (Basel). 2018 Mar 1;9(3):134. doi: 10.3390/genes9030134.
Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other "pieces of the RNA puzzle". These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis. Moreover, some are still considered housekeeping RNAs, for instance small nucleolar RNAs (snoRNAs) and TERC. Our review summarizes the biogenesis, mechanism of action and potential role of less known ncRNAs in head and neck cancer, with a particular focus on the installment and progress for this particular cancer type.
以前被忽视的非编码RNA（ncRNAs）已成为许多研究的主题。然而，ncRNAs受到的关注程度存在不均衡。一些转录本，如微小RNA（miRNAs）或小干扰RNA（siRNAs），已备受关注，但有必要研究其他“RNA拼图碎片”。这些能提供关于正常和病理细胞行为更完整的视角。其他ncRNA种类较少被研究，要么是因为它们最近才被发现，如稳定内含子序列RNA（sisRNA）、YRNA、miRNA偏移RNA（moRNA）、端粒酶RNA组分（TERC）、天然反义转录本（NAT）、转录超保守区域（T-UCR）和假基因转录本，要么是因为它们在很大程度上仍被视为与发病机制无关的非编码转录本。此外，一些仍被视为管家RNA，例如小核仁RNA（snoRNAs）和TERC。我们的综述总结了鲜为人知的ncRNAs在头颈癌中的生物发生、作用机制和潜在作用，特别关注这种特定癌症类型的发生和进展。
