Hauptman Paul J, Swindle Jason P, Masoudi Frederick A, Burroughs Thomas E
Department of Medicine, Division of Cardiology, Saint Louis University School of Medicine, St Louis, MO 63110, USA.
Circ Cardiovasc Qual Outcomes. 2010 Mar;3(2):204-11. doi: 10.1161/CIRCOUTCOMES.109.880450. Epub 2010 Mar 2.
Current guidelines emphasize the need for optimal medical therapy before implantation of cardiac devices (implantable cardioverter-defibrillator, cardiac resynchronization therapy). Our objective was to evaluate use of beta-blockers (BB) among patients with heart failure undergoing a cardiac device procedure.
We used a large, multistate, managed-care database (January 2003 to December 2006) to identify adults admitted with an International Classification of Diseases, Ninth Revision (ICD-9) procedure code for cardiac device, continuous enrollment for 180 days before and 180 days after device procedure, and a primary or secondary ICD-9 diagnosis code for heart failure during that period. Our primary measures were use of BB before device procedure and changes after discharge. A total of 2766 beneficiaries (78.8% men; median age, 61 years) underwent a device procedure for primary prevention. The median number of days on BB therapy in the 90 days before device procedure was 46. Beneficiaries who did not have a pharmacy fill for BB during that time (n=925, 33.4%) were more elderly and had fewer antecedent outpatient visits with a cardiologist. There was a shift toward greater use of BB after device procedure; 83.4% had at least 1 pharmacy fill for a BB during follow-up.
BB are underused before and after cardiac device procedures. There is a modest increase in use after the procedure. Strategies are required to ensure that patients are on optimal medical therapy before device therapy is selected.
当前指南强调在植入心脏设备(植入式心律转复除颤器、心脏再同步治疗)之前进行最佳药物治疗的必要性。我们的目标是评估在接受心脏设备手术的心力衰竭患者中β受体阻滞剂(BB)的使用情况。
我们使用了一个大型的多州管理式医疗数据库(2003年1月至2006年12月),以识别因国际疾病分类第九版(ICD-9)心脏设备手术代码入院的成年人,在设备手术前180天和手术后180天持续参保,以及在此期间心力衰竭的主要或次要ICD-9诊断代码。我们的主要指标是设备手术前BB的使用情况以及出院后的变化。共有2766名受益人(78.8%为男性;中位年龄61岁)接受了一级预防的设备手术。设备手术前90天接受BB治疗的中位天数为46天。在此期间未进行BB药房配药的受益人(n = 925,33.4%)年龄更大,之前看心脏病专家的门诊次数更少。设备手术后BB的使用有所增加;83.4%的人在随访期间至少有1次BB药房配药。
在心脏设备手术前后,BB的使用不足。手术后使用量有适度增加。需要采取策略以确保在选择设备治疗之前患者接受最佳药物治疗。