Su Tong, Liu Bing, Zhao Yifang
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Feb;35(2):176-81. doi: 10.3969/j.issn.1672-7347.2010.02.015.
To observe the change of vascular endothelial cells and structure of the auricular posterior vein caused by freezing or pingyangmycin injection alone and freezing in combination with pingyangmycin injection,to investigate the effect of these treatments on the vein.
Eighteen rabbits were divided into 3 groups of 6 each, and another rabbit was used as a control. Pingyangmycin was injected into the auricular posterior vein in the first group, spray freezing within 20 seconds on the auricular posterior vein was performed in the second group,and freezing in combination with pingyangmycin injection was performed in the third group. Light microscope and transmission electron microscope were used to observe the change of auricular posterior vein in the rabbits.
Proliferation of endothelial cells,and thickening of vessel wall were induced by pingyangmycin. Thrombus formation, tissue oedema and inflammatory infiltration induced by spray freezing within 20 seconds were reversible. Thrombus formation, proliferation of endothelial cells and thickening of the vessel wall was induced by freezing in combination with pingyangmycin injection.
Freezing and pingyangmycin injection have the synergistic effect, resulting in the proliferation of endothelial cells, thrombus formation, thickening of vessel wall, and even occlusion of vessels.
观察单纯冷冻或平阳霉素注射以及冷冻联合平阳霉素注射对兔耳后静脉血管内皮细胞及血管结构的变化，探讨这些治疗方法对静脉的影响。
将18只家兔分为3组，每组6只，另取1只家兔作为对照。第一组向兔耳后静脉内注射平阳霉素，第二组对兔耳后静脉进行20秒内喷雾冷冻，第三组进行冷冻联合平阳霉素注射。采用光学显微镜和透射电子显微镜观察兔耳后静脉的变化。
平阳霉素可诱导内皮细胞增生及血管壁增厚。20秒内喷雾冷冻诱导的血栓形成、组织水肿和炎症浸润是可逆的。冷冻联合平阳霉素注射可诱导血栓形成、内皮细胞增生及血管壁增厚。
冷冻与平阳霉素注射具有协同作用，可导致内皮细胞增生、血栓形成、血管壁增厚，甚至血管闭塞。
