颈项透明层测量质量对 13 三体和 18 三体检出率的影响。
Impact of quality of nuchal translucency measurements on detection rates of trisomies 13 and 18.
机构信息
Department of Obstetrics and Gynecology, Mt. Sinai School of Medicine, New York, NY, USA.
出版信息
Fetal Diagn Ther. 2010;27(2):68-71. doi: 10.1159/000291490. Epub 2010 Mar 2.
OBJECTIVE
To determine the relative contribution of nuchal translucency (NT) to the biochemical detection rates of combined screening for trisomies 13 and 18 in two healthcare systems practicing different quality-control systems of nuchal measurement.
METHODS
De-identified data collected from the Fetal Medicine Foundation in the United Kingdom and laboratory data from NTD laboratories in the United States were compared for detection rate and false-positive rate (FPR) for combined trisomies 13 and 18 screening and were subcategorized by biochemical only and biochemistry combined with NT measurement.
RESULTS
US and UK biochemical detection rates were virtually identical: 83% for a FPR of 1.8%. When NT measurement was added, the US rate increased to 88% for a 0.7 FPR, but in the UK the rate increased to 94% for a FPR of 0.3%. The mean NT was 1.69 mm in the US and 2.82 mm in the UK.
CONCLUSIONS
NT measurement as practiced in the UK system with tight quality control significantly increased the detection rate and significantly reduced the FPR of combined screening for trisomies 13 and 18, when compared to the US with apparently less rigid quality control.
目的
确定在两个医疗保健系统中，颈项透明层（NT）对三体 13 和 18 联合筛查的生化检测率的相对贡献，这两个系统实施了不同的颈项测量质量控制系统。
方法
对比英国胎儿医学基金会的已识别数据和美国 NTD 实验室的实验室数据，比较三体 13 和 18 联合筛查的检测率和假阳性率（FPR），并按仅生化和生化结合 NT 测量进行分类。
结果
美国和英国的生化检测率几乎相同：FPR 为 1.8%时为 83%。当添加 NT 测量时，美国的比率增加到 0.7 FPR 时的 88%，但在英国，FPR 为 0.3%时的比率增加到 94%。美国的平均 NT 为 1.69 毫米，英国为 2.82 毫米。
结论
与美国系统相比，英国系统实施了严格的质量控制，颈项透明层测量显著提高了三体 13 和 18 联合筛查的检测率，并显著降低了假阳性率，而美国系统的质量控制显然不太严格。
Zotero 插件