Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, Japan.
Dig Dis Sci. 2010 Nov;55(11):3181-7. doi: 10.1007/s10620-010-1159-8. Epub 2010 Mar 3.
There are currently no studies examining the relationship between systemic inflammatory response and distant metastasis in colorectal cancer patients.
The aim of this study was to evaluate the association of a systemic inflammatory response on distant metastasis by examining clinicopathological factors in patients with colorectal cancer infiltrating the submucosal layer (T1) or the proper muscular layer (T2).
Univariate analysis was performed to evaluate the influence of a systemic inflammatory response on distant metastasis in patients with T1 or T2 colorectal cancer using collected clinicopathological data.
Between 1993 and 2008, 156 patients with pathologically diagnosed T1 or T2 colorectal cancer were enrolled. Univariate analysis using clinicopathological factors and Glasgow Prognostic Score (GPS) (0, 1/2) demonstrated that, as well as lymph node metastasis, administration of oral anti-cancer drug and CEA, CRP (odds ratio, 36.25; 95% CI 4.026-326.4; P = 0.001) and GPS (odds ratio, 24.50; 95% CI 1.715-349.9; P =0.018) were associated with distant metastasis.
CRP and GPS are associated with distant metastasis of T1 or T2 colorectal cancer. Because of the small number of patients with stage IV disease (n =4), a multi-center retrospective study is needed to confirm these findings.
目前尚无研究探讨结直肠癌患者全身炎症反应与远处转移之间的关系。
本研究旨在通过检查结直肠黏膜下层（T1）或固有肌层（T2）浸润患者的临床病理因素，评估全身炎症反应对远处转移的影响。
采用单因素分析方法，根据收集的临床病理资料，评估 T1 或 T2 结直肠癌患者全身炎症反应对远处转移的影响。
1993 年至 2008 年间，共纳入 156 例经病理诊断为 T1 或 T2 结直肠癌患者。单因素分析显示，除淋巴结转移、口服抗癌药物和 CEA 外，CRP（优势比，36.25；95%可信区间，4.026-326.4；P=0.001）和 GPS（优势比，24.50；95%可信区间，1.715-349.9；P=0.018）与远处转移有关。
CRP 和 GPS 与 T1 或 T2 结直肠癌的远处转移有关。由于 IV 期疾病患者数量较少（n=4），需要进行多中心回顾性研究来证实这些发现。
