College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
AAPS J. 2010 Jun;12(2):223-32. doi: 10.1208/s12248-010-9181-5. Epub 2010 Mar 3.
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment options for pancreatic cancer. Moreover, the review discusses the opportunities of developing novel therapies for pancreatic cancer provided by the progress in understanding the genetic mutations, tumor microenvironment, cancer stem cells, and drug delivery.
胰腺癌是美国癌症相关死亡的第四大主要原因。高死亡率部分归因于缺乏有效的治疗方法。本文综述了胰腺癌的病理生物学和当前治疗选择。此外，还讨论了通过对遗传突变、肿瘤微环境、癌症干细胞和药物输送的理解进展为胰腺癌开发新疗法提供的机会。
