Jörres R A, Welte T, Bals R, Koch A, Schnoor M, Vogelmeier C
Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin der LMU München.
Dtsch Med Wochenschr. 2010 Mar;135(10):446-9. doi: 10.1055/s-0030-1249185. Epub 2010 Mar 2.
The integrated project COSYCONET, as part of the competence network ASCONET funded by the BMBF, has the aim to investigate the relationship between the pulmonary disorder, comorbidities and systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) by adopting cross-sectional as well as longitudinal analyses.
COSYCONET includes a number of projects addressing the issue of comorbidities at the basic science level. Its core project, however, is the establishment of a cohort of patients with COPD, which is compared with two population-based control cohorts. The COPD cohort will include 3,000 patients, among them 1,500 with severity according to GOLD category I/II and 1,500 with category III/IV. Patients will be recruited in study centers covering all major regions of Germany, and this will be achieved in close cooperation with pneumologists from private practices. After recruitment, patients will be studied upon an initial visit as well as 6 and 18 months later. Each visit includes a comprehensive battery of functional tests and questionnaires that aim at assessing the state of the disease as accurately and completely as feasible, comprising lung function and the individual pattern and risk factors of comorbidities including cardiovascular disorders, metabolic disorders, osteoporosis, exercise capacity, acticity and mental status. In addition blood samples will be taken and asservated in a biobank in order to assess markers of systemic inflammation and aging as well as organ-specific markers. Moreover morphological information on the lung as available from HR-CT pictures that have not been specifically taken for the study will be analysed semi-quantitatively in a central facility and standardised manner.
作为由德国联邦教育与研究部资助的能力网络ASCONET的一部分，综合项目COSYCONET旨在通过横断面分析和纵向分析，研究慢性阻塞性肺疾病（COPD）患者的肺部疾病、合并症与全身炎症之间的关系。
COSYCONET包括多个在基础科学层面解决合并症问题的项目。然而，其核心项目是建立一个COPD患者队列，并将其与两个基于人群的对照队列进行比较。COPD队列将包括3000名患者，其中1500名病情严重程度为GOLD I/II级，1500名病情严重程度为III/IV级。患者将在覆盖德国所有主要地区的研究中心招募，这将与私人诊所的肺科医生密切合作来实现。招募后，患者将在首次就诊时以及6个月和18个月后接受研究。每次就诊都包括一系列全面的功能测试和问卷，旨在尽可能准确和全面地评估疾病状态，包括肺功能以及合并症的个体模式和风险因素，如心血管疾病、代谢紊乱、骨质疏松症、运动能力、活动情况和精神状态。此外，还将采集血样并保存在生物样本库中，以评估全身炎症和衰老的标志物以及器官特异性标志物。此外，将在一个中央设施以标准化方式对并非专门为该研究拍摄的高分辨率CT（HR-CT）图像中可得肺部形态学信息进行半定量分析。
