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肾脏教育推广计划的社区筛查:参与者的人口统计学特征和筛查结果。

The Kidney Education Outreach Program's community-based screenings: participants' demographics and screening results.

作者信息

Harward Donna H, Bomback Andrew S, Jennette Caroline E, Amamoo M Ahinee, Falk Ronald

机构信息

UNC Kidney Center, USA.

出版信息

N C Med J. 2009 Nov-Dec;70(6):507-12.

Abstract

OBJECTIVE

To outline the Kidney Education Outreach Program (KEOP) screening protocol, to describe the context in which these chronic kidney disease (CKD) screenings were administered, and to report the characteristics and screening results for participants from October 2005 to September 2008.

METHODS

A cohort of 1742 people participated in targeted, free, community-based CKD screenings. Screenings included a self-report questionnaire regarding sociodemographic information, lifestyle behaviors, and personal and family health history. This survey was followed by urine dipstick testing for proteinuria and microalbuminuria.

RESULTS

Medical histories were provided by 1694 individuals: 1522 through the complete questionnaire and 172 through an abbreviated questionnaire that differed principally in lack of information on family history of disease. Urine samples were collected from 1706 participants. The mean age of screening participants was 54 years old; 70% were female, 50% were African American, and 13% were Latino. More than 40% of subjects were obese. Roughly one-quarter (23%) had been diagnosed with diabetes mellitus and about half (47%) had been diagnosed with hypertension. Twenty-four percent reported a family history of kidney disease. While 60% of the participants tested positive for microalbuminuria, less than 4% of these persons had ever been told they had kidney disease.

LIMITATIONS

Lack of confirmatory testing with a serum creatinine (and estimated glomerular filtration rate) or, alternatively, with a 24-hour urine collection for creatinine clearance and protein excretion; no standardized follow-up for screened participants.

DISCUSSION

The KEOP targeted screenings disclosed a high prevalence of known risk factors for CKD--diabetes mellitus, hypertension, obesity, advanced age, and family history of kidney disease. However, despite these factors, less than 4% of screened participants were aware of a diagnosis of CKD.

摘要

目的

概述肾脏教育外展计划(KEOP)的筛查方案,描述进行这些慢性肾脏病(CKD)筛查的背景情况,并报告2005年10月至2008年9月期间参与者的特征及筛查结果。

方法

1742人参与了有针对性的、免费的、基于社区的CKD筛查。筛查包括一份关于社会人口学信息、生活方式行为以及个人和家族健康史的自我报告问卷。该调查之后是进行尿试纸条检测以筛查蛋白尿和微量白蛋白尿。

结果

1694人提供了病史:1522人通过完整问卷,172人通过简略问卷,简略问卷主要区别在于缺少疾病家族史信息。从1706名参与者中收集了尿液样本。筛查参与者的平均年龄为54岁;70%为女性,50%为非裔美国人,13%为拉丁裔。超过40%的受试者肥胖。约四分之一(23%)的人被诊断患有糖尿病,约一半(47%)的人被诊断患有高血压。24%的人报告有肾脏疾病家族史。虽然60%的参与者微量白蛋白尿检测呈阳性,但这些人中不到4%曾被告知患有肾脏疾病。

局限性

缺乏血清肌酐(和估算肾小球滤过率)的确诊检测,或者缺乏用于肌酐清除率和蛋白质排泄的24小时尿液收集检测;对筛查参与者没有标准化的随访。

讨论

KEOP的针对性筛查揭示了CKD已知危险因素的高患病率——糖尿病、高血压、肥胖、高龄以及肾脏疾病家族史。然而,尽管存在这些因素,筛查参与者中不到4%的人知晓自己被诊断患有CKD。

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