Ohira Y, Kaga K, Kodama A
Department of Otolaryngology, Teikyo University School of Medicine, Tokyo.
Nihon Jibiinkoka Gakkai Kaiho. 1991 Jan;94(1):9-15. doi: 10.3950/jibiinkoka.94.9.
We report temporal bone pathology in a 25-year-old man with bilateral temporal bone adenocarcinoma which was caused by metastasis from a primary lesion in the pancreas. The initial symptoms began with vertigo and headache and the patient noticed left hearing loss in the left ear on the following day. A few days later, he noticed hearing loss in the right ear, and bilateral hearing was totally lost within two weeks of the onset. In addition to severe bilateral sensorineural hearing loss, left IInd, bilateral Vth and VIIIth cranial nerve paralysis occurred. Brain CT showed multiple metastatic lesions in the brain. The patient's general condition rapidly deteriorated, and he died of acute pneumonia on the 42nd day after onset. At autopsy it was revealed adenocarcinoma of the tail and body of the pancreas and its metastasis to the brain and meninges. Pathological study of the temporal bone showed infiltration of carcinomatous cells along the VIIth and VIIIth nerves in the bilateral internal auditory canals.
我们报告了一名25岁男性双侧颞骨腺癌的颞骨病理学情况，该腺癌由胰腺原发性病变转移所致。最初症状为眩晕和头痛，患者次日注意到左耳听力丧失。几天后，他又注意到右耳听力丧失，发病两周内双耳完全失聪。除严重的双侧感音神经性听力丧失外，还出现了左侧面神经Ⅱ级、双侧三叉神经Ⅴ级和位听神经Ⅷ级麻痹。脑部CT显示脑部有多个转移病灶。患者的一般状况迅速恶化，发病后第42天死于急性肺炎。尸检发现胰腺体尾部腺癌并转移至脑和脑膜。颞骨病理研究显示双侧内耳道内癌细胞沿面神经Ⅶ级和位听神经Ⅷ级浸润。
