.Division of Paediatrics, Oslo University Hospital, Oslo, Norway.Department of Endocrinology, Oslo University Hospital, Oslo, Norway.
Acta Paediatr. 2010 May;99(5):770-773. doi: 10.1111/j.1651-2227.2010.01701.x. Epub 2010 Mar 1.
The chronic fatigue syndrome is associated with alterations in the hypothalamus-pituitary-adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among adolescent chronic fatigue syndrome patients and healthy controls regarding antidiuretic hormone, the renin-angiotensin-aldosterone-system, sex hormones and cardiac peptides.
We included a consecutive sample of 67 adolescents aged 12-18 years with chronic fatigue syndrome diagnosed according to a thorough and standardized set of investigations, and a volunteer sample of 55 healthy control subjects of equal gender and age distribution. Hormones were assayed with standard laboratory methods.
Among patients, plasma antidiuretic hormone was significantly decreased and serum osmolality and plasma renin activity were significantly increased (p < or = 0.001). Serum concentration of aldosterone, cortisol, NT-proBNP and sex hormones were not significantly different in the two groups.
Chronic fatigue syndrome in adolescents is associated with alterations in hormonal systems controlling osmolality and blood volume, possibly supporting a theory of central dysregulation.
慢性疲劳综合征与下丘脑-垂体-肾上腺轴和心血管自主神经活动的改变有关，提示存在中枢失调。本研究探讨了青少年慢性疲劳综合征患者与健康对照组之间抗利尿激素、肾素-血管紧张素-醛固酮系统、性激素和心肽的差异。
我们纳入了一组连续的 67 名 12-18 岁的青少年慢性疲劳综合征患者，根据一套全面而标准化的检查进行诊断，同时纳入了 55 名性别和年龄分布相同的健康志愿者作为对照组。采用标准实验室方法检测激素。
患者组的血浆抗利尿激素显著降低，血清渗透压和血浆肾素活性显著升高（p≤0.001）。两组间血清醛固酮、皮质醇、NT-proBNP 和性激素浓度无显著差异。
青少年慢性疲劳综合征与控制渗透压和血容量的激素系统改变有关，可能支持中枢失调的理论。
