Huang Yu-Jun, Wu Shao-Guo, Ou Xiao-Bing, Zhang Li
Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):85-8.
To study the value of iron metabolism indices, serum iron (SI), total iron blinding capacity (TIBC) and transferring (Tf), in thalassema.
The serum samples from 9 children with silent alpha thalassema, 56 with standard alpha thalassema, 26 with HbH disease, 40 with beta+ thalassema, 56 with beta0 thalassema, 45 with iron deficiency anemia (IDA) and 70 healthy children were detected for SI, TIBC and Tf levels.
The SI level increased (p<0.01), while the TIBC level decreased significantly in the beta0 thalassema group compared with those in the other groups (p<0.05 or 0.01), but the Tf level was not different. The Tf level of both the silent alpha thalassema and the standard alpha thalassema groups was statistically lower than that of the healthy group (p<0.01), but the levels of SI and TIBC were similar to the healthy group. Though the SI level of the HbH disease group was similar to the healthy group, the TIBC and Tf levels were statistically lower (p<0.01).
Compared with Tf, SI and TIBC are better indices for monitoring iron loading in children with thalassema. The increased SI level and decreased TIBC level are two indices for the diagnosis of beta(0) thalassema in children with cellule anaemia.
研究铁代谢指标血清铁（SI）、总铁结合力（TIBC）和转铁蛋白（Tf）在地中海贫血中的价值。
检测9例静止型α地中海贫血患儿、56例标准型α地中海贫血患儿、26例血红蛋白H病患儿、40例β+地中海贫血患儿、56例β0地中海贫血患儿、45例缺铁性贫血（IDA）患儿及70例健康儿童的血清SI、TIBC和Tf水平。
与其他组相比，β0地中海贫血组SI水平升高（p<0.01），TIBC水平显著降低（p<0.05或0.01），但Tf水平无差异。静止型α地中海贫血组和标准型α地中海贫血组的Tf水平均低于健康组（p<0.01），但SI和TIBC水平与健康组相似。血红蛋白H病组SI水平与健康组相似，但TIBC和Tf水平低于健康组（p<0.01）。
与Tf相比，SI和TIBC是监测地中海贫血患儿铁负荷的更好指标。SI水平升高和TIBC水平降低是诊断细胞贫血患儿β(0)地中海贫血的两个指标。
