[幽门螺杆菌感染患儿胃黏膜中凋亡相关蛋白的表达]

[Expression of apoptosis-related proteins in gastric mucosa of children with Helicobacter pylori infection].

作者信息

Liu Wei-Ping, Sun Su-Fang, Zhang Gui-Li

机构信息

Xihua County People's Hospital, Zhoukou, Henan 466600, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):110-2.

PMID:20199724

Abstract

OBJECTIVE

To investigate the relationship between apoptosis-related proteins in gastric mucosa, p53 and Bax, and Helicobacter pylori (H. pylori) infection in children.

METHODS

p53 and Bax expression in gastric mucosa were measured using immunohistochemical technique in 33 children with gastric mucosal lesions. Presence/absence of H. pylori infection was detected by the rapid urease and pathological tests.

RESULTS

Fifteen children (88%) showed positive expression of p53 in 17 children who were confirmed with H. pylori infection, compared with 9 (56%) in 16 H. pylori negative children. Thirteen children (76%) showed positive expression of Bax in the 17 children with H. pylori infection, compared with 6 (38%) in the 16 H. pylori negative children. The expression levels of p53 and Bax in the H. pylori positive group were significantly higher than those in the H. pylori negative group (p<0.05).

CONCLUSIONS

H. pylori infection is associated with the over-expression of p53 and Bax proteins in gastric mucosa in children.

摘要

目的

探讨儿童胃黏膜中凋亡相关蛋白p53和Bax与幽门螺杆菌（H. pylori）感染之间的关系。

方法

采用免疫组化技术检测33例胃黏膜病变患儿胃黏膜中p53和Bax的表达。通过快速尿素酶试验和病理检查检测是否存在H. pylori感染。

结果

17例确诊为H. pylori感染的患儿中，15例（88%）p53呈阳性表达，而16例H. pylori阴性患儿中9例（56%）呈阳性表达。17例H. pylori感染患儿中，13例（76%）Bax呈阳性表达，而16例H. pylori阴性患儿中6例（38%）呈阳性表达。H. pylori阳性组中p53和Bax的表达水平显著高于H. pylori阴性组（p<0.05）。