Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Vaccine. 2010 Apr 26;28(19):3440-4. doi: 10.1016/j.vaccine.2010.02.071. Epub 2010 Mar 1.
The serotype of 172 S. pneumoniae isolates obtained from normally sterile sites from January 2006 to February 2009 in Thai patients was evaluated. The most common serotypes were 6B, 23F, 14, 19F, and 19A in patients <5 year-old, and 6B, 19A, 23F, 4, 9V in patients >65-year old. Seven-valent pneumococcal conjugated vaccine (PCV-7) covered 70.3%, 43.6%, and 43.5% of patients <5, 5-64 and > or = 65 years of age, respectively, while PCV-13 covered 81.2%, 59.7%, and 60.9%, respectively. PCV-9, PCV-10, PCV-11 had very similar coverage as PCV-7. The antibiotic susceptibility rates of the isolates from sterile sites were 88.7-95.7% for penicillin, 90.6-98.4% for cefotaxime, 92.2-100% for ofloxacin and 100% for ciprofloxacin. PCV-7 covered 83% and 100%, respectively, of penicillin and cefotaxime non-susceptible isolates in patients <5-year old.
从 2006 年 1 月至 2009 年 2 月，对从泰国无菌部位分离的 172 株肺炎链球菌血清型进行了评估。5 岁以下患者最常见的血清型为 6B、23F、14、19F 和 19A，65 岁以上患者最常见的血清型为 6B、19A、23F、4、9V。7 价肺炎球菌结合疫苗（PCV-7）分别覆盖了<5 岁、5-64 岁和≥65 岁患者的 70.3%、43.6%和 43.5%，而 13 价肺炎球菌结合疫苗（PCV-13）则分别覆盖了 81.2%、59.7%和 60.9%。PCV-9、PCV-10 和 PCV-11 与 PCV-7 的覆盖范围非常相似。无菌部位分离株对青霉素的药敏率为 88.7-95.7%，对头孢噻肟的药敏率为 90.6-98.4%，对左氧氟沙星的药敏率为 92.2-100%，对环丙沙星的药敏率为 100%。PCV-7 分别覆盖了<5 岁青霉素和头孢噻肟非敏感分离株的 83%和 100%。
