肾上腺皮质发育与肿瘤：聚焦 SF-1。
Adrenocortical development and cancer: focus on SF-1.
机构信息
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
出版信息
J Mol Endocrinol. 2010 Jun;44(6):301-7. doi: 10.1677/JME-09-0143. Epub 2010 Mar 3.
PMID:20200142
Abstract
Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice.
摘要
类固醇生成因子-1（SF-1/Ad4 结合蛋白；NR5A1）是类固醇生成细胞中组织特异性基因表达和肾上腺性腺发育的必需调节因子。在这里，我将讨论文献中的最新数据，这些数据表明 SF-1 的作用及其剂量的重要性，不仅在发育过程中，而且在人类和小鼠的肾上腺皮质肿瘤发生中也是如此。
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