Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Maryland, USA.
J Immunol. 2010 Apr 1;184(7):3331-5. doi: 10.4049/jimmunol.0903022. Epub 2010 Mar 3.
The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2(-/-) mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c(+) dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.
人源和鼠源的甲酰肽受体样 1（现为 FPR2）通过与其相关的炎症和免疫反应配体，介导白细胞迁移。为了明确该受体的体内作用，我们构建了 mFPR2 基因敲除的小鼠。mFPR2(-/-) 小鼠在卵清蛋白/氢氧化铝诱导的过敏性气道炎症中，其严重程度明显降低。这与气道黏膜和次级淋巴器官中 CD11c(+)树突状细胞的募集减少，以及 2 型细胞因子和 Igs 的产生减少有关。我们还发现，具有气道炎症的野生型小鼠的支气管肺泡灌洗液中含有 mFPR2 激动剂活性。本研究揭示了 mFPR2 在过敏性气道炎症和免疫反应进展中的关键作用。
