Lim Lina H K, Pervaiz Shazib
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
FASEB J. 2007 Apr;21(4):968-75. doi: 10.1096/fj.06-7464rev. Epub 2007 Jan 10.
The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with a significant degree of biological and structural homology (40-60%). First described in the late 1970s and subsequently referred to as macrocortin, renocortin, lipomodulin, lipocortin-1, and more recently Annexin 1, this 37 kDa calcium and phospholipid binding protein is a strong inhibitor of glucocorticoid-induced eicosanoid synthesis and PLA2. Recent interest in the biological activity of this intriguing molecule has unraveled important functional attributes of Annexin 1 in a variety of inflammatory pathways, on cell proliferation machinery, in the regulation of cell death signaling, in phagocytic clearance of apoptosing cells, and most importantly in the process of carcinogenesis. Here we attempt to present a short review on these diverse biological activities of an interesting and important molecule, which could be a potential target for novel therapeutic intervention in a host of disease states.
膜联蛋白超家族由13种钙或钙与磷脂结合蛋白组成，它们在生物学和结构上具有高度同源性（40%-60%）。该家族在20世纪70年代末首次被描述，随后被称为大皮质素、肾皮质素、脂调素、脂皮质素-1，最近又被称为膜联蛋白1，这种37 kDa的钙与磷脂结合蛋白是糖皮质激素诱导的类花生酸合成和磷脂酶A2的强效抑制剂。最近对这种有趣分子的生物活性的研究揭示了膜联蛋白1在多种炎症途径、细胞增殖机制、细胞死亡信号调节、凋亡细胞的吞噬清除以及最重要的致癌过程中的重要功能特性。在此，我们试图对这个有趣且重要的分子的这些多样生物活性进行简要综述，它可能是许多疾病状态下新型治疗干预的潜在靶点。
