Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):844-9. doi: 10.1158/1055-9965.EPI-09-0699. Epub 2010 Mar 3.
Oral lichen planus (OLP) is a potentially malignant disorder associated with an increased risk for oral cancer. The purpose of this study was to determine protein expression of podoplanin and ATP-binding cassette, G2 subfamily (ABCG2) in patients with OLP and evaluate their use as biomarkers for OLP malignant transformation risk.
Podoplanin and ABCG2 expressions were determined in samples from 110 patients with untransformed OLP and 9 patients with malignant transformed OLP (mean follow-up of 5.1 years). We compared podoplanin expression, ABCG2 expression, and clinicopathologic parameters between the two groups.
Podoplanin expression was observed in 48 of 110 (43.6%) cases of untransformed OLP and in 8 of 9 (88.9%) cases of transformed OLP. ABCG2 expression was found in 23 of 110 (20.9%) cases of untransformed OLP and in 6 of 9 (66.7%) cases of transformed OLP. Multivariate regression analysis revealed that podoplanin or ABCG2 expression was associated with 17.13-fold [95% confidence interval (95% CI), 1.71-171.22; P = 0.016] or 6.04-fold (95% CI, 1.20-30.36; P = 0.029) increased risk of malignant transformation, respectively. The risk of OLP malignant transformation was considerably higher with coexpression of podoplanin and ABCG2 than without coexpression of podoplanin and ABCG2 (odds ratio, 25.24; 95% CI, 4.48-142.27; P < 0.001).
The expressions of podoplanin and ABCG2 in OLP were significantly associated with malignant transformation risk.
Our data suggested that podoplanin and ABCG2 may be used as biomarkers for risk assessment of oral malignant transformation in patients with OLP.
口腔扁平苔藓（OLP）是一种潜在的恶性疾病，与口腔癌风险增加有关。本研究的目的是确定口腔扁平苔藓患者中 podoplanin 和三磷酸腺苷结合盒，G2 亚家族（ABCG2）的蛋白表达，并评估它们作为口腔扁平苔藓恶性转化风险的生物标志物。
在 110 例未转化的 OLP 患者和 9 例恶性转化的 OLP 患者的样本中确定 podoplanin 和 ABCG2 的表达。我们比较了两组之间 podoplanin 表达、ABCG2 表达和临床病理参数。
在 110 例未转化的 OLP 病例中，有 48 例（43.6%）和 9 例（88.9%）恶性转化的 OLP 病例中观察到 podoplanin 表达。在 110 例未转化的 OLP 病例中有 23 例（20.9%）和 9 例（66.7%）恶性转化的 OLP 病例中发现了 ABCG2 表达。多变量回归分析显示，podoplanin 或 ABCG2 表达与 17.13 倍（95%置信区间（95%CI），1.71-171.22；P=0.016）或 6.04 倍（95%CI，1.20-30.36；P=0.029）的恶性转化风险增加相关。与 podoplanin 和 ABCG2 共表达相比，无 podoplanin 和 ABCG2 共表达时 OLP 恶性转化的风险明显更高（比值比，25.24；95%CI，4.48-142.27；P<0.001）。
口腔扁平苔藓中 podoplanin 和 ABCG2 的表达与恶性转化风险显著相关。
我们的数据表明，podoplanin 和 ABCG2 可作为评估口腔扁平苔藓患者口腔恶性转化风险的生物标志物。
